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Some investigators have proposed that glutathione depletion is a common mechanism underlying multiple age-related diseases, making it a therapeutic target for healthy aging [10][11]

In another study, it was found that L-theanine antagonized cannabinoid receptor 1 and inhibited its activity, relieved the inhibition of cannabinoid receptor 1 on COX-2 expression, reduced the pro-inflammatory factor TNF-, and enhanced the anti-inflammatory factor IL-10, making L-theanine show a significant regulatory effect on the immune function of normal and E44813-stressed rats (97)

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By activating the same receptors the natural hormone uses, they reproduce its appetite-regulating and metabolic effects at a clinical level

A data sharing statement provided by the authors is available with the full text of this article at NEJM.org